Reticular pseudodrusen is a finding of morphological changes to the retina associated with various conditions, such as AMD, choroidal neovascularization and geographic atrophy.1 But uncovering that finding hasn’t always been easy. However, with the development of retinal multimodal imaging, researchers are finding a higher incidence of reticular pseudodrusen than in previous studies that used fundus color images.2
French researchers looked at data from 472 eligible eyes. They identified an annual reticular pseudodrusen incidence per participant of 2.9% and an estimated 13.5% five-year incidence.2 Age, choroidal thinning and genetic background were all associated with incident reticular pseudodrusen, whereas lipophilic statin therapy was associated with a lower risk.2
After a multivariable analysis, the team identified four risk factors: subfoveal choroidal thinning and those carrying minor allelic variants for ARMS2, CFH or LIPC.2
1. Wightman A, Guymer R. Reticular pseudodrusen: current understanding. Clin Exp Optom. 2019;102(5):455-62.
2. Dutheil C, Le Goff M, Cougnard-Grégoire A, et al. Incidence and risk factors of reticular pseudodrusen using multimodal imaging. JAMA Ophthalmol. March 12, 2020. [Epub ahead of print].