Mesopic dysfunction was found following previous predominant rod-mediated function loss, whereas the overall highest functional loss was detected with development of cRORA lesions.
Following cataract surgery, the pathology developed in 23% of eyes with filtering lens implants and 19% without. Mean annual increases, however, were 0.78mm2 and 1.26mm2, respectively.
The most significant inner retinal alterations were observed in those with late-stage disease and/or GA, while little difference was noted between early and intermediate macular degeneration.
This revision—accounting for reticular pseudodrusen and GA—shows that progression rates are substantially higher when using a more comprehensive approach.
Study also finds intraretinal fluid results in a fast-progressing disease, and these patients tend to be older at the time of diagnosis and remain on treatment for a shorter time.
Understanding these features may help disease diagnosis in Asian populations. Patients with the former subtype were significantly younger, predominantly male and had a slower progression rate.
Progression is positively associated with non-exudative subretinal fluid and hyperreflective material as well as iRORA. It’s negatively associated with retinal pseudocysts and subfoveal choroid thickness.