Optometric Physician

 

 


Vol. 25, #25 •   Monday, July 15, 2024

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Off the Cuff: Simple, Yet Effective


One of the most exciting aspects of treating dry eye and ocular surface disease is the seemingly constant stream of innovation ranging from novel therapeutic molecules to high-tech treatment devices. However, sometimes innovation can come in relatively simple packages. Several months ago, before Vision Expo East, my friend Joe Boyd emailed me about a new startup he was working with. The product was an irrigating device for the ocular surface developed by a retinal specialist in Pittsburgh. My initial reaction was one of relative uncertainty as to where such a device would fit in our current dry eye protocol—what could a simple saline rinse achieve beyond what our advanced treatments could already offer? However, I try to keep an open mind when it comes to new therapies, so I set up a meeting with Joe and Srini Kondapalli, the creator of the device.

 

I was introduced to Rinsada, an irrigating lid retractor, a device that attaches to the end of a syringe and allows for a high-pressure rinse of the conjunctival fornices and ocular surface by hooking beneath the lids and jetting water into these difficult-to-reach spaces. The high-pressure jets of water that are created by the device likely allow it to “strip” the tear film from the ocular surface at a deeper level, much like power washing an oil and dirt coated driveway, which essentially allows us to manually reset the tear film. Srini initially got the idea for the device from the rinse he performs on his patients after instilling betadine for intraocular injections. He also shared some early data that showed a decrease in inflammatory factors on the ocular surface after use, which is beneficial given that it is well-established that dry eye patients have increased levels of inflammatory factors present in the tear film and on the ocular surface. I initially performed a one-eyed trial on my tech, Danae, a long-time dry eye sufferer and contact lens wearer, and the next day she could tell a difference in comfort between the irrigated and untreated eye.

I am now routinely performing Rinsada with NuLids PRO to pair this ocular surface lavage with microblepharoexfoliation—essentially cleaning the ocular surface inside and out. This also fits well in the oft-discussed “dental model” of ocular surface care, as the vast majority of patients (if not every patient given our screen-centric lifestyles) would likely benefit from such routine cleanings performed at least once or twice a year. Additionally, I have found it useful in cases where patients have allergies, an excessively mucoid tear film, or the ubiquitous “I feel like there is something under my eyelid” complaint. As I look forward to finding more uses for this new device, I am reminded that sometimes all innovation needs to be is simple, yet effective.




Cory J. Lappin, OD, MS, FAAO
cjlappinod@gmail.com

 


Want to share your perspective?
Write to Dr. Shannon L. Steinhäuser, OD, MS, FAAO at ssteinhauser@gmail.com. The views expressed in this editorial are solely those of the author and do not necessarily represent the opinions of Jobson Medical Information LLC (JMI), or any other entities or individuals.




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Widefield OCT Imaging Improves Rate of Change Detection in Progressing Glaucomatous Eyes Compared With Standard-Field Imaging


Forty-five eyes of 25 healthy individuals and 263 eyes of 161 glaucoma patients from the Diagnostic Innovations in Glaucoma Study were evaluated to compare rates of retinal nerve fiber layer change over time in healthy eyes with non-progressing glaucoma and eyes with progressing glaucoma using single widefield (SWF) and optic nerve head (ONH) cube scan optical coherence tomography (OCT) images. All eyes underwent 24-2 visual field testing and OCT (Spectralis SD-OCT) ONH and macular imaging. SWF images (up to 43° × 28°) were created by stitching together ONH cube scans centered on the optic disc and macular cube scans centered on the fovea. Visual field progression was defined as guided progression analysis, likely progression and/or a significant mean deviation slope of less than -1.0 dB/year. Mixed effects models were used to compare rates of change. Highly myopic eyes were included.

Thirty glaucomatous eyes were classified as progressing. In eyes with glaucoma, mean global rate of change was -1.22 µm/year using SWF images and -0.83 µm/year using ONH cube scans. Rate of change was significantly greater in eyes with progressing glaucoma compared with eyes with non-progressing glaucoma (-1.51 µm/year vs. -1.24 µm/year) using SWF images and was similar using ONH cube scans.

In this cohort that included eyes with and without high axial myopia, the mean rate of retinal nerve fiber layer thinning measured using SWF images was faster in eyes with progressing glaucoma than in eyes with non-progressing glaucoma. Researchers concluded that widefield OCT images including the ONH and macula can be effective for monitoring glaucomatous progression in patients with and without high myopia.

SOURCE: Christopher Bowd, Akram Belghith, Jasmin Rezapour, et al. Wide-Field Optical Coherence Tomography Imaging Improves Rate of Change Detection in Progressing Glaucomatous Eyes Compared With Standard-Field Imaging. Invest Ophthalmol Vis Sci. 2024 Jul 1;65(8):18.


 


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Prevalence of Dry Eye Disease in LASIK Candidates


These researchers evaluated the prevalence of dry eye disease (DED) in laser-assisted in situ keratomileusis (LASIK) candidates. A chart review of consecutive LASIK candidates who underwent full ocular surface work-up was performed, including ocular surface disease index (OSDI), noninvasive tests (noninvasive tear breakup time [ni-TBUT], tear meniscus height, lipid layer thickness, and meibography), and invasive tests (Schirmer test I, fluorescein TBUT, corneal staining, and meibomian gland [MG] expressibility). The prevalence of DED was calculated according to the Dry Eye Workshop II (DEWS II), and Japanese and Asia Dry Eye Society (JDES/ADES) criteria.

In total, 135 patients (270 eyes) were evaluated. The mean age was 32.6±8.3 years, and 62.9% were women (n=85); 19 patients (15.4%) wore contact lenses, and 31 patients (23.8%) used artificial tears. The mean OSDI was 18.2±16.9, which was abnormal in 54.1% (n=62). Inferior lid MG dropout was the sign with the highest percentage of abnormal results (61.5%; n=83). There were no differences between men and women in any test except for ni-TBUT (6.3±0.3 and 7.2±0.2, respectively). Dry eye disease prevalence was 25.9% and 53.3%, according to JDES/ADES and DEWS II criteria, respectively. The only significant risk factor for DED was artificial tear use for both DEWS II and JDES/ADES.

This study found a high prevalence of DED and abnormalities in LASIK candidates, highlighting the importance of ocular surface evaluation before photorefractive surgery.

SOURCE: Cristian Cartes, Camila Aravena, Alejandro Monsalve, et al. Prevalence of Dry Eye Disease in Laser-Assisted In Situ Keratomileusis Candidates. Eye Contact Lens. 2024 Jul 1;50(7):305-310.

Comparative Analysis of Changes in Retinal Layer Thickness Following Femtosecond Laser-Assisted Cataract Surgery and Conventional Cataract Surgery


These researchers investigated the influence of femtosecond laser-assisted cataract surgery (FLACS) on the macula by examining changes in retinal layers after FLACS and compared the changes with those after conventional cataract surgery (CCS). This study included 113 unrelated Korean patients with age-related cataract who underwent CCS or FLACS in Severance Hospital between September 2019 and July 2021. Optical coherence tomography was performed before and 1 month after surgery. The total retinal layer (TRL) was separated into the inner retinal layer (IRL) and outer retinal layer (ORL); moreover, the IRL was subdivided into the retinal nerve fiber layer, ganglion cell layer, inner plexiform layer, inner nuclear layer (INL), outer plexiform layer, and outer nuclear layer. Researchers performed between-group comparisons of the postoperative thickness in each retinal layer and the postoperative differences in retinal thickness. The average retinal thickness of the four inner macular ring quadrants was used for comparative analysis.

Compared with the CCS group, the FLACS group exhibited a thicker ORL and a thinner INL after surgery. All retinal layer thickness values showed significant postoperative changes regardless of the type of surgery. The postoperative increase in TRL and IRL thickness was significantly smaller in the FLACS group than in the CCS group.

The 1-month postoperative retinal changes were less pronounced in the FLACS group than in the CCS group.

SOURCE: Dongheon Surl, Seungmin Kim, Sangyeop Kim, et al. Comparative analysis of changes in retinal layer thickness following femtosecond laser-assisted cataract surgery and conventional cataract surgery. BMC Ophthalmol. 2024 Jul 9;24(1):276.

 

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Industry News


New National Survey Shows Dry Eye Sufferers Struggle to Find Relief


Bausch + Lomb’s inaugural State of Dry Eye survey revealed the majority of respondents may not know that their symptoms—which can include redness, fluctuating vision, a scratchy, gritty, tired or heavy feeling, or overall eye irritation—may be associated with eye dryness. Additionally, most respondents may not realize that symptoms of dry eye are increasingly present in younger people, and two in five are unaware that untreated dry eye can lead to other eye problems, such as fluctuating vision. The research was conducted online in the United States by The Harris Poll on behalf of Bausch + Lomb among 2,003 U.S. adults 18 years or older including 461 “sufferers” (defined as those who often/always experience eye dryness and/or have been diagnosed by a healthcare professional with dry eye disease) and 1,542 non-sufferers. The survey was conducted April 15 to 23, 2024. Read more.



Alcon Completes Acquisition of Belkin Vision, Expanding Glaucoma Portfolio with DSLT Device


Alcon announced the closing of its deal to acquire Belkin Vision with a total upfront consideration of $81 million, including a cash payment of approximately $65 million. The deal also includes the potential for up to $385 million in payments, contingent upon rigorous sales-based milestones. The acquisition includes Belkin Vision’s Direct Selective Laser Trabeculoplasty technology, expanding Alcon’s glaucoma portfolio with a first-line therapy. For glaucoma, Alcon also offers implantables such as the Hydrus Microstent and pharmaceutical drops, available in the United States. Read more.


Announcements


• iCare announced a partnership with Evertreen to promote extensive reforestation efforts and address critical environmental challenges as part of a commitment to sustainability. Read more.
• WaveRFID, a provider of inventory management technology, and Crystal Practice Management (PM), a provider of eye care practice management systems, announced a new integration aimed at streamlining inventory management processes for eye care providers. Eye care professionals using Crystal PM can seamlessly sync their inventory data with WaveRFID’s RFID technology, which is capable of scanning over 1000 items in less than 10 minutes. Read more.

 

 

 

 

 

 














 
Journal Reviews Editor:
Shannon L. Steinhäuser, OD, MS, FAAO

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