One paper helped isolate ocular hypertensives at a low risk of disease conversion. The other screened high- and low-risk patients and found a correlation between PRS and new diagnoses of POAG.
Researchers speculate that the ensuing stagnation may cause an accumulation of neurodegenerative factors; another theory involves compartmentalization of the optic nerve sheath.
A Danish study of 30,000 patients found increasing age, female sex and low comorbidity score were correlated with better diligence with eye drop treatment for up to 10 years.